# Get targeted mRNA

On a miRNA list, in order to perform biological interpretation, the targeted mRNA with gene symbol information is needed - gene symbol is used to map to the pathway database

On a data node contains miRNA list, e.g. differential analysis result data, **Biological interpretation > Get targeted mRNA** task will be enabled.

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Database like TargetScan can be used to get targeted mRNAs for a specific mRNA. Specify the database in the dialog, and click **Finish**.

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Double click on the Targeted mRNA node to open the report

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* Context++ score: estimating the strength of repression, more negative values suggest stronger predicted repression, this is the key metric for ranking predicted targets
* Context++ score percentile: percentile ranking of the score compared to all predictions, higher percentile means stronger predicted effect
* Weighted Context++ score: adjusted score considering multiple sites in the same transcript
* Predicted relative KD: predicted relative dissociation constant is to measure the affinity between miRNA and targeted mRNA, lower KD means stronger binding affinity, higher KD means weaker binding.