# Adding a Variant Effect Predictor (VEP) Database

Click the **+ Add VEP database** button under the *VEP database* section on the [library file management page](https://help.multiomics.illumina.com/icm/analyses/analysis-functionality/settings/library-file-management/broken-reference).

If you are using an species supported by Connected Multiomics (i.e., human, mouse), a VEP database from [ENSEMBL](http://www.ensembl.org/info/data/ftp/index.html) will be available for automatic download. Select the **Download database** radio button and click **Create** (Figure 1).

<figure><img src="https://580316046-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2FWMxqQAMFOJtu98OBk9KN%2Fuploads%2Fgit-blob-da794400654368b6b0b4e9b3a6c749c1dc048561%2Fimage%20(445).png?alt=media" alt=""><figcaption><p align="center">Figure 1. For certain model organisms, automatic downloads of VEP databases are available.</p></figcaption></figure>

If you are working with a custom assembly, choose the **Import database** radio button and click **Create** (Figure 1). A VEP database can be added from your local computer by clicking the option of *My Computer.* ENSEMBL maintains an extensive list of VEP databases for various species. We recommend going to [ENSEMBL's ftp download site](http://www.ensembl.org/info/data/ftp/index.html) and finding the VEP database download link for your species of interest.

One VEP database is allowed per genome assembly. Once a VEP is successfully imported, the **+ Add VEP database** button will not be shown (Figure 2).

<figure><img src="https://580316046-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2FWMxqQAMFOJtu98OBk9KN%2Fuploads%2Fgit-blob-1a9a0a9b2b3289556ecb61cb8b505bc454de3bc2%2Fimage%20(446).png?alt=media" alt=""><figcaption><p align="center">Figure 2. Successful addition of a VEP database library file.</p></figcaption></figure>
